Functional Respiratory Imaging: A New Tool? A Chat with Jan De Backer.

 

Jan de Backer is an aerospace engineer who, in concert with his respirologist father, designed an AI system that, from HRCT, can extract a ton of information about lung parenchymal, airway and vascular structure. With no contrast or anything. Just from a run-of-the-mill CT chest…

In full disclosure, I have (unfortunately!) no connection or interest in Fluidda (www.fluidda.com)  outside of a clinical one.

So I’ve been meaning to speak with Jan whose tweets about functional respiratory imaging (FRI) and the FLUIDDA technology have been really piquing my interest, but its taken me unfortunately too long to do so, but here it is. I think this is fascinating technology, which is currently available to all freely (COVID times and all…), and in my opinion clearly deserves a trial run and some clinical experiences. If you are interested, drop me a line and I will link you up with Jan De Backer.

Here is the vid:

 

Here is the audio:

 

So if you are a fan of bedside physiology and personalized medicine, be sure not to miss H&R Reloaded, which will be packed with cutting and bleeding edge talks and faculty – a lot of the stuff we’ve been talking about is not what’s currently being done, or about and I think we just might have to add a talk on FRI…

APRV & COVID Respiratory Failure with Spiegel & Farkas. #FOAMed, #FOAMcc

So at our last webinar (still to be edited due to an unfortunate trolling event), we briefly touched on modes of ventilation but really didn’t delve into it very deeply, so, being fortunate enough to know some really smart people, I figured I might gather up these two for a quick chat. They are both known for no-nonsense, out-of-the-box thinking, paired with solid physiological thinking, which in my mind is the only way to approach complex problems and system failure. Plus, with Rory (@EMnerd) and his powerful nihilistic approach, there would be no chance for a whimsical approach, it would have to have a base in physiology, evidence (bedside or literature) or both!

So just as a little brain teaser, I would like anyone reading to think about how many severe respiratory failure syndromes they are aware of that attack the lungs in a predictable volumetric fashion, where one can say, for instance, that consistently, X% of the parenchyma is affected. Kinda hard, huh? Yet, if asked how best to ventilate these patients, most of us who feel we have a good grasp of severe respiratory failure would answer without thinking twice: “lung protective ventilation: good peep and 4-6 ml/kg.” In a lear, confident tone, most likely as well.

Now I would say that only the first part is correct: lung protective ventilation. As to the second part, it would, to me, only hold true with uniform pathology and uniform patients. But I’ll let Rory rant about that himself, it’s far more entertaining!

So here is our chat.

Hope everyone gets something out of it!

 

cheers

 

Philippe

Re-Thinking the Early Intubation Paradigm of COVID-19: Time to Change Gears? #FOAMed#CO

So we wrote this up last week, but the (relatively) slow process of submission made us decide to just go ahead and release it as pure #FOAMed literature, because while highly relevant and somewhat controversial 10 days ago, it is now almost already accepted!  What an incredible (in all senses of the word) time we are in…

So here are our thoughts:

 

I think it is important to clarify that none of us are saying that ventilators should NOT be used. HFNC or NIV approaches will not avoid intubation and mechanical ventilation for all patients, only for some, and for those it doesn’t, mechanical ventilation is an absolute life-saver. For many laypeople and perhaps non-critical care or acute care physicians, this may have been lost in much of the social media discussion…

For anyone interested in the development of the CAB-RSS score, do get in touch, we are in the process of an inter-observer validity study and eventually will integrate in a decision making algorithm.

 

cheers

 

Philippe

COVID-19 Webinar: Respiratory Management #FOAMed #FOAMcc

 

So I had an awesome time talking and learning from some of the smartest and most progressive thinkers I know, some of the usual suspects at H&R, and some amazing docs from Italy and NYC who are at the front lines of this COVID war.

Programme

  • HFNC & NIV – do we dare use them? 
  • when do we intubate?
  • how do we ventilate? prone ventilation routine or rescue?
  • Adjuncts: suction, bronchoscopy
  • When do we wean?
  • Q&A if time allows.

Panelists:

Dr. Laura V. Duggan MD FRCPC (Anesthesiology and Pediatrics), Associate Professor, Department of Anesthesiology and Pain Medicine, University of Ottawa, Canada @drlauraduggan. www.airwaycollaboration.org

Dr. Marco Garrone, MD, ED doc from Mauriziano Ospedale, Torino, Italy. @drmarcogarrone.

Dr. Cameron Kyle-Sidell, MD, ED-ICU, Maimonides Hospital, New York. @cameronks

Dr. Josh Farkas, ICU, University of Vermont, Creator, The Internet Book of Critical Care (IBCC), @pulmcrit.

Dr. Adam Thomas, ED doc & CC Fellow, University of British Columbia, co-author, The Internet Book of Critical Care, @adamdavidthomas.

Dr. Philippe Rola, ICU, Santa Cabrini Hospital, Montreal, Quebec. @thinkingcc

Dr. Rory Spiegel, ED-CC doc, Washington Hospital Center, Washington, DC. @emnerd

Dr. Scott Weingart, ED-CC doc, Creator, EmCrit.org, Stony Brook Hospital, New York. @emcrit

Here is the audio, am working on editing the video and should have it up soon.

I realize many questions came from the audience regarding L and H phenotypes, a concept which was rapidly assimilated by those reading and discussing day and night to stay at the cutting edge of the understanding of COVID physiology, so I am including the Gattinoni paper which is the source. For those still thinking of this as ARDS, understand that the single most published author and pre-eminent authority on that disorder states “this is not ARDS,” even if the H type, for those who progress to it – or evolve towards it due to initial management strategies, is fairly similar.

Gattinoni COVID

A huge thanks again to my all star cast for making this happen and for their continuing efforts to learn and teach. Please refer to Josh and Adam’s IBCC covid page which is constantly evolving, and Scott’s emcrit.org for ongoing info.

Webinar Audio:

 

Webinar video

 

There were a lot of comments and questions, many very interesting, will try to address them in the next webinar likely in a week or so.

 

cheers and stay safe

 

Philippe

COVID-19 – Respiratory Management: A Physiological Approach. #FOAMed, #FOAMcc, #COVID19

Hi,

So we’ve got a pretty good lineup of docs who have been taking care of COVID patients for the last few weeks assembled, including one who had pretty much seen it all from the Italian battlefront. We’ve got anaesthesia, critical care and emergency medicine representatives. As usual, we’ll be trying to bring highly physiological and practical approaches to managing the respiratory failure of this new disease we are all facing.

So this is #FOAMed, but I just found out that the max meeting size is 500. So I guess it is first come first served. Asking everyone who is not a panelist to stay muted please, those not adhering to this will be promptly booted out as it completely ruins audio quality. It should be recorded if the cloud doesn’t fail and will be available on this blog.

Questions can be sent on twitter to @ross_prager who will set us up, please use #thinkingcovid.

Join the Webinar here!

Programme

8pm EDT (GMT-4) Welcome panelists & intro

  • HFNC & NIV – do we dare use them? 
  • when do we intubate?
  • how do we ventilate? prone ventilation routine or rescue?
  • Adjuncts: suction, bronchoscopy
  • When do we wean?
  • Q&A if time allows.

Panelists:

Dr. Laura V. Duggan MD FRCPC (Anesthesiology and Pediatrics), Associate Professor, Department of Anesthesiology and Pain Medicine, University of Ottawa, Canada @drlauraduggan. www.airwaycollaboration.org

Dr. Marco Garrone, MD, ED doc from Mauriziano Ospedale, Torino, Italy. @drmarcogarrone.

Dr. Cameron Kyle-Sidell, MD, ED-ICU, Maimonides Hospital, New York. @cameronks

Dr. Josh Farkas, ICU, University of Vermont, Creator, The Internet Book of Critical Care (IBCC), @pulmcrit.

Dr. Adam Thomas, ED doc & CC Fellow, University of British Columbia, co-author, The Internet Book of Critical Care, @adamdavidthomas.

Dr. Philippe Rola, ICU, Santa Cabrini Hospital, Montreal, Quebec. @thinkingcc

Dr. Segun Olusanya, Anaesthesia-ICU, Reading, England. @iceman_ex

Dr. Rory Spiegel, ED-CC doc, Washington Hospital Center, Washington, DC. @emnerd

Dr. Scott Weingart, ED-CC doc, Creator, EmCrit.org, Stony Brook Hospital, New York. @emcrit

COVID Clinical Discussions: An Update w Dr. Garrone. Sharing CPAP??? #FOAMed

Incredible discussion with front-line italian ED doc Marco Garrone (@drmarcogarrone – follow him on twitter for great covid POCUS cases). Chilling for those of us not yet in the storm, but very interesting stuff, especially the use of NIV-sharing – two patients simultaneously on CPAP.

Here is the audio:

 

For more on vent sharing and references, please see Josh’s post here!

stay safe

 

Philippe

COVID-19 Clinical Discussions – Dr. Blair Schwartz. #FOAMed

Tonight I had a chance to chat with Dr. Blair Schwartz, intensivist at the Jewish General Hospital in Montreal, Canada, one of the ministry-designated COVID centers, in part due to their ICU which was designed with pandemics in mind and able to physically be divided in sealed-off halves. Impressive stuff.

Here is our chat:

So thus far, the small Montreal experience parallels what we have heard from the Chinese and Italian experiences: they crash fast, so intubate them early, then deal with a high compliance ARDS that is difficult to oxygenate, and prone them. Oh yeah and the critically ill are not the very elderly at least so far…

Oh yes and I also questioned Blair on whether they were re-using N95s or staying completely protected for the day – seems to have been a practice in some of the dedicated areas in China, but so far, given “only” 3 patients they are keeping the general unit “clean” and disposing of all PPE between patients.

We’ll keep tabs on the evolution of the critically ill cases and try to share anything useful.

Here are my other COVID links: POCUS & COVID and Clinical Discussions.

Scott has a great video on COVID preox here:

And if you are running out of vents be sure to check out Josh Farkas’s post here on increasing your patient to ventilator ratio!

Jonny Wilkinson’s fantastic COVID page.

 

wash your hands & stay safe

 

Philippe

 

POCUS and COVID: Practical & Clinical Applications. #FOAMed

So I’ve yet to take care of any COVID patients, but we are ramping up, and it’s just a matter of time. In the meantime, practical issues such as where we will cohort patients and how we protect non-COVID patients and HCPs are happening, and one of the challenges in infection control is imaging, which is a staple of severe respiratory illness.

Evidence has been steadily coming out that lung ultrasound is carving itself a pivotal role in the diagnosis and management of COVID infection. Here are some of the things I’ve gathered and I think are worth sharing. I will be adding to this as I collect from others and eventually generate a COVID POCUS database and experience.

a. Lung US is more sensitive than CXR for interstitial patterns, small effusions and subpleural thickening. 

b. COVID seems to have some particular ultrasound features:

from:

Full article: COVID LUS

c. POCUS can be used to detect worsening or improvement of disease – by personal communication of Italian and Chinese ER/ICU docs. No published data yet, but several self-scanning infected physicians corroborate clinical improvement with resolution of POCUS lung findings.

d. POCUS can also detect the usual pathologies!  Pneumothorax is not a rare occurence in ventilated patients, and there may be an increased rate related to the parenchymal damage resulting in the unusually high compliance respiratory failure.

 

COVID POCUS DATA

Here is a good example from Marco Garrone with COVID B line pattern on the left, along with pleural thickening and small sub-pleural consolidations, note also the clustering of B lines, compared to the left, B lines of CHF with a relatively smooth and even pleural line:

This is a great article by Yi et al, a Chinese radiology group, with some great CT/POCUS comparative images:

LUS covid study

 

BOTTOM LINE

This makes it important that all physicians and probably also PAs and nurses pick up basic LUS skills. At our shop we are making sure all first line providers can screen for lung POCUS abnormalities.

 

BASIC LUNG POCUS

Lung ultrasound modules have been made open access at USABCD!

here are some excellent first steps by Jacob Avila:

How I perform the Lung Ultrasound Exam

B Lines

Pneumothorax

 

 

COVID-19 Clinical Discussions with Dr. Marco Garrone & Dr. Peng Zhiyong. #FOAMed

COVID19 has made for a rough start to 2020 for humans. Now ramping up in Canada, we can only hope that lessons learnt in China and Italy by governments and medical teams can be applied in a timely enough fashion to flatten the curve and allow our already stretched-thin healthcare system to absorb it without dire consequences for both COVID and non-COVID patients.

At my shop we have started our (re)organizational plan for the potential storm that may hit us.

So here is my chat with Marco (@drmarcogarrone)

And here is the vidconf audio with Dr. Zhiyong

 

I apologize for the prolonged ending there were technical difficulties and we ended up losing Dr. Zhiyong’s connection at the end.

Some clinical points from these and other discussions:

high compliance ARDS

– needs peep, but avoid hi peep as seems to have high risk of pneumothorax. This may make sense given high compliance may reflect alveolar wall elastic fiber damage.

avoid NIV including HFNC unless negative pressure room to prevent aerosolization.

may need to use N95 for entire duration of rounds in hot zone ICU to save stock

– personally, I would/will consider early proning or modified proning for spontaneously breathing patients (not on NIV either, just face mask).

LUS for screening dx and f/u (see below)

 

Other COVID resources:

Splitting ventilators for multiple patients https://emcrit.org/pulmcrit/split-ventilators/

Covid effects on cardiovascular system https://www.nature.com/articles/s41569-020-0360-5.pdf

Chinese experience with LUS: https://link.springer.com/article/10.1007/s00134-020-05996-6

My friend Jonny Wilkinson (@wilkinsonjonny) put together a great page with a ton of resources here at criticalcarenorthhampton.

My EMCrit Teammates Josh and Scott have put together some great clinical points as well, especially some practical tips for respiratory support setups and airway management.

IBCC a super comprehensive chapter on COVID.

EMCRIT on airway management.

And here are some excellent documents on hospital preparedness, ethics, a ventilatory support infographic from our italian colleagues as well as some kindly shared clinical notes and tips.

covid-19-checklist-hospitals-preparing-reception-care-coronavirus-patients

italian_triage_ethics (1)

ESICM info

SIAARTI – Covid-19 – Airway Management rev.1.1

COVID notes March 11 (1)

Also, as this will undoubtedly be a time for stress for HCPs caring for COVID patients, a respirologist friend of mine shared a link to a wellness/meditation tool, the coronavirus survival guide which has been made freely available to us. Now I have not tried it yet but I trust Andy.

Comment from anaesthetist Dr. Marco Vergone who is on the front line in Turin, Italy:

We are using prone positioning in almost all of our patients that require invasive mechanical ventilation, we’re trying alternate lateral position for patients on CPAP (helmet), and personally I find very promising prone positioning for patients in spontaneous breathing during weaning from CPAP, before discharge from the ICU.
I can confirm that diagnostic (CT and XR) is really burdensome when you have many isolated ICU patients, so lung US becomes paramount for bedside daily evaluation.
We’re working on standardized protocols for different levels of expertise of colleagus (pro level, basic skills, beginners).
For intubation procedures, we perform rapid sequence with ketamine + rocuronium or fentanil+propofol+rocuronium and ALWAYS videolaryngoscope. We always clamp the tube before disconnections and we always sop gas flow before removing helmets of masks. Apart from correct use of PPE, it is paramount to reduce aerosolization and contamination of the environment.
Get prepared ASAP, and stay strong!
Best, M

hope some of this can help other HCPs in these trying times.

 

Philippe