Bedside Ultrasound & Intracavitary Thrombolysis: Using the Ajmo sign. #FOAMed, #FOAMcc, #FOAMus

So as a follow up to a recent post about intra-abdominal thrombolysis, here is a little pearl from a colleague and fellow ICU physician, Dr. Ian Ajmo.

The Ajmo sign refers to the visualization of injected contrast in a fluid cavity, used to confirm proper position of a drainage catheter in an effusion or ascites.

In the case of a separated effusion, it is often difficult to determine if the septations are truly divisive of the fluid, or just a network of membranes that remain communication and that a single catheter can drain. I have seen both cases with similar echo graphic appearance.

However, the Ajmo sign can be used to determine of the catheter is likely to drain the bulk of the collections, or if the use of thrombolytics should be considered:


In this case, we can see that the agitated saline fills only one of the cavities with little or no spillover into adjacent pockets of pleural fluid. This is a case where thrombolytics can be considered. Hence, this consideration can be done early using bedside ultrasound, rather than follow up CT scans (notoriously poor at seeing fine separations).




Bedside Ultrasound for neuro-assessment in the ICU: another interesting case! #FOAMed, #FOAMcc, #FOAMus

So a woman in her 40’s was discovered unresponsive at home and emergently brought to hospital. She was known for severe rheumatoid arthritis and had had two CVAs in the past. She had unfortunately suffered from distrust and noncompliance.

An emergency cricothryrotomy was done for a difficult airway which, due to difficulty ventilating (no cuff in our cric kit) was exchanged to a 6.0 ETT over a tube exchanger. Unfortunately our CT scan was up for maintenance, so the CT head was delayed.

Our working diagnosis was another CVA with an aspiration pneumonia.

So of course we had to pick up the probe and take a look:




So the optic nerves are dilated significantly (bilaterally), suggesting an ICP over 20 mmhm at the very least.

Next the TCD waveform (from the left temporal area):


It was fairly difficult to find a good vessel, and likely at a bifurcation hence a narrow and bidirectional spike on doppler. The signal noise made it difficult to look clearly at diastolic flow and make a definitive call of circulatory arrest.

However, there is a clear asymmetry in the hemispheres (not due to gain difference), with the distal hemisphere (RT) showing increased echogenicity:


Also, there is a midline shift:


This suggested an acute and severe process in the right hemisphere. A few hours later, the CT scan showed the following:


After family discussion, we withdrew therapy.

So one of the questions a colleague asked is whether I would have been comfortable making the call of an acute and severe process at the bedside and deciding to withdraw therapy, and at this point, I would have said no, in this particular case where the TCD signal wasn’t quite clean enough, and in a center with CT scan availability. I could, however, see a clinical scenario where, with a better TCD signal, I might do so, especially if I were in a remote area.





So to answer my colleague’s question about “calling it,” I reached out to the one who first started me in CNS ultrasound, Dr. Robert Chen (@ottawaheartrob), who had this very, very insightful comment (originally on his blog)

Can you “call it” with CNS POCUS?
A dear friend and colleague wrestled with a difficult situation.

A patient, who despite chronic diseases had distanced themselves from the medical system. Found collapsed, a long and hard fought resuscitation ensued. Airway challenges, ventilation and oxygenation challenges had to be overcome as part of a prolonged code. After Return of Spontaneous Circulation (ROSC), attention turned to the neurologic exam. Beyond the clinical history of prolonged cardiac arrest with the complicating hypoxaemia, the clinical exam was non-reassuring. Technical factors delayed access to CT scanning of the brain.

Optic nerve sheath ultrasound (an anatomic assessment) suggested raised ICP. Transcranial Doppler suggested the physiology of raised ICP. 2D grey scale ultrasound imaging of brain demonstrated asymmetry (yes, the team was THAT good). The question: should one stop resuscitation based on CNS POCUS alone?.

“Calling it” in resuscitation has a long history of being based on the clinical history and clinical examination alone. Think of the many “code blues” that you have attended. Many efforts have terminated with the team having decided that the patient could not be resuscitated without any imaging modalities employed, point of care (POC) or other. “Calling it” with POC ultrasound (POCUS) starts its history in the emergency department which eventually became the American College of Surgery’s Committee on Trauma (ACS COT) codified Focused Abdominal Sonography in Trauma (FAST). Patients were sent for laparotomy or subxipoid pericardial window based on POCUS alone. POCUS, in great urgency offered the clinician improved access to diagnosis and thus improved access to resuscitation direction for the patient.

What about “Calling it” for brain injury? Does the faster access to resuscitation mean something in this situation?

CT scans of the brain are the standard of care in this situation. POCUS has never meant to replace standard imaging modalities (echocardiography by cardiology, abdominal imaging by radiology, vascular Doppler, etc.) but rather to augment the physical examination, screen for time critical injuries and offer easy repeatability particularly in time sensitive situations. Which POCUS element is important in this case? None and all.

Would one stop CNS resuscitation without knowing the mechanism or resuscitatability of the CNS injury without a CT scan? Even in the hands of a vascular Doppler lab, transcranial Dopplers are supportive tests at best for neurologic determination of death (as opposed to ancilliary tests: 4 vessel angio, CT angio or scintigraphy). Stopping resuscitation at this phase (ROSC) based on POCUS would put the patient into a palliative mode as opposed to stopping a code wherein the previous diagnosis of death and non-resuscitatability is acknowledged.

Still, should they have “called it”? POCUS does another wonderful thing. It asks the clinician to touch their patient. Rather than being the acute care quarterback (often recording the nurses vital signs rather than performing their own) who orders “STAT ECG, CKs, troponins, and get cardiology here to do an echo” the POCUS able clinician spends a few more seconds examining and speaking to the patient, often offering the patient more clinical information quickly.

POCUS in this case in the hands of a caring clinician may do something different: when speaking to family they would be able to express that patient had perhaps already declared their intention through distancing themselves from the medical system. As well, they would be able to say “After I examined her, I was so worried that I did my own testing. I did a focused brain ultrasound which makes me very concerned that something terrible has happened: a stroke, a bleed, a tumour, something bad. What I would have normally done is order a CT scan of her head and then possibly call a neurosurgeon. What would she want me to do?”

POCUS brings us closer to out patients. We examine them for longer. Describing POCUS results and their significance in a contemporary fashion to the patient and/or their loved ones forces us to communicate more.

Stop CNS resuscitation without tomographic imaging in Canada? No. Understand CNS anatomy and physiology better through POCUS? Sure. Become a better CNS resuscitator as a result? Probably. Communicate better to patients and families at the end of life through POCUS? A strong possibility.

Resuscitation Leadership Academy: Check it out!


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Just wanted to invite everyone to take a look at the Resuscitation Leadership Academy (www.resuscitationleadership academy), brainchild of Haney Mallemat (@criticalcarenow) and Scott Weingart (@emcrit), neither of whom need an intro at this point, needless to say.  Much thanks to them for inviting me to the faculty, very honoured to be a part of the team!

Basically the RLA offers an online curriculum packed with great material, but more importantly the opportunity to do an online hangout with any faculty member and discuss cases, topics, etc, in an informal but very informative manner. I think this is a great resource for trainees as well as those who are in practice but either lack an academic environment or really just want to tap into some of these guys’ experience and knowledge.

Looking forward to meeting some of you in a hangout!



Intra-abdominal thrombolysis for septated SBP: a case. #FOAMed, #FOAMcc

So we had an interesting case this week of an alcoholic cirrhotic fellow in his 60’s who was admitted with SBP, septic and in respiratory failure. A pigtail had been inserted (RLQ) a few days ago successfully draining 3 litres of cloudy ascites which grew morganella and e.coli. Obviously he was treated with antibiotics.

When I took him over on a monday morning he was hemodynamically stable but with a distended and tense abdomen. A quick look with bedside ultrasound revealed significant but highly septated ascites, and the pigtail had been draining little in the last 24 hours.


We decided to insert a second pigtail in this area, which immediately drained only 30-40 cc, and decided to use TPA to loosen things up a bit (we used 2mg TPA in each pigtail).  In the following 12 hours, the original pigtail drained 700 cloudy cc’s and the new one, 1,000 cc’s. We repeated the TPA for two more doses but little more came out. No bleeding, and he was on prophylactic anticoagulation.

Just thought I’d put the case out there to add to the intra-abdominal thrombolysis data, which is substantially less than the pleural, and, as usual, to show how routine use of bedside ultrasound reveals things you’d either never otherwise see (loculations on CT???  Naaaah.), be guessing about, or have to wait and move your patient to CT.







Here is a nice little review on lysis: sir04264