So I just finished listening to the second podcast of The Resuscitationists’ Awesome Guide to Everything (www.ragepodcast.com), and as advertised, it is totally awesome. It’s really cool to have the point of view of several bright acute care clinicians whose field of expertise obviously overlaps but have different perspective in terms of experience and setting.
In episode 2, they do a great review of the MOPETT trial and thrombolysis in PE in general, and really work at distilling clinical information from academic literature, which is ultimately what has to be done. The hashing out of the finer points by using specific clinical scenarios is really, really good.
I have personally applied the MOPETT half dose TPA twice with good success, both in young patients and after explaining the risks and benefits. As in full dose thrombolysis, the clinical improvements in minutes to hours of massive/submassive PEs are quite remarkable.
So much kudos and everyone interested enough to read this should most definitely be checking them out, I know I’ll be!